Exosome Therapy

What Are Exosomes?

Exosomes are tiny extracellular vesicles, typically 30 to 150 nanometres in size, released by various cells in the body, including stem cells, immune cells, and epithelial cells. They act as natural messengers, carrying important biological signals from one cell to another.

Each exosome is packed with a rich cargo of growth factors, proteins, messenger RNA (mRNA), microRNA (miRNA), lipids, and signalling molecules that influence how other cells behave. These molecules play critical roles in:

• Tissue regeneration

• Cell communication

• Inflammation control

• Healing and repair

In dermatology, exosomes used for therapeutic purposes are typically derived from cultured mesenchymal stem cells (MSCs), known for their regenerative potential. The exosomes are isolated and purified in highly controlled laboratory conditions, resulting in a cell-free product that delivers powerful regenerative instructions without introducing live cells into the body.

Because exosomes do not contain cells, they present a lower risk of immune reactions or rejection, making them a safe and effective option for non-invasive hair restoration.

How Exosome Therapy Works for Hair Loss

Hair loss occurs for many reasons, including genetics, hormonal imbalance, inflammation, stress, and scalp ageing. Exosome therapy works by restoring balance in the scalp environment and reactivating dormant hair follicles using regenerative signals.

Here’s how exosomes support hair regrowth:

1. Delivery of Bioactive Signals

Exosomes are rich in biologically active molecules such as epidermal growth factor (EGF), fibroblast growth factor (FGF), and vascular endothelial growth factor (VEGF). These molecules directly stimulate hair follicle stem cells, improving follicular activity and promoting the growth of stronger, thicker hair.

2. Reducing Inflammation

Chronic inflammation is a major contributor to hair follicle miniaturisation. Exosomes contain anti-inflammatory cytokines and miRNAs that help calm the immune response and reduce oxidative stress, creating a healthier scalp environment conducive to hair growth.

3. Improving Blood Flow

Exosomes stimulate angiogenesis, the formation of new blood vessels, which enhances scalp circulation. Improved blood flow ensures hair follicles receive the oxygen and nutrients they need to thrive.

4. Prolonging the Anagen Phase

The anagen phase is the active growth period in the hair cycle. Exosomes help extend this phase while reducing the duration of the resting (telogen) phase, resulting in denser, fuller hair over time.

5. Enhanced Delivery via Microneedling

At Shine Dermatology, exosome therapy is often combined with microneedling, which creates microchannels in the scalp for better penetration. Microneedling also triggers the body’s natural healing response, further enhancing the effectiveness of the treatment.

Summary of Effects on the Hair Growth Cycle:

Who Is a Good Candidate for Exosome Therapy?

Exosome therapy may be suitable for:

• Men and women with androgenetic alopecia (male or female pattern baldness)

• Individuals with diffuse thinning or increased hair shedding

• Patients who prefer non-surgical and low-downtime treatments

• People seeking options beyond conventional topicals or oral medications

Our dermatologists will evaluate your scalp health and hair loss type before recommending exosome therapy as part of a tailored treatment plan.

What to Expect During the Procedure

1. Consultation and Diagnosis
A full assessment of your hair loss condition, lifestyle, and medical history will be performed.

2. Scalp Preparation
The scalp is thoroughly cleansed, and a topical anaesthetic may be applied to enhance comfort.

3. Exosome Application
Exosomes are delivered to areas of concern using fine microneedling techniques.

4. Post-Treatment Care
You may experience mild redness or tingling that usually subsides within 24–48 hours. Detailed aftercare instructions will be provided.

How Many Sessions Are Needed?

Most patients benefit from 3 to 5 sessions, spaced approximately 4 to 6 weeks apart. While individual responses vary, visible improvements in density, texture, and scalp condition typically begin to appear by the second or third month.

For maintenance, a booster session may be recommended every 6 to 12 months.

Is Exosome Therapy Safe?

Yes. Exosome therapy is a non-surgical, minimally invasive treatment that is well tolerated by most individuals. The exosomes we use are sourced from international laboratories with stringent quality and sterility controls.

Unlike stem cell therapy, exosomes are cell-free, reducing the risks associated with immune rejection or abnormal tissue growth. Common side effects, if any, are mild and temporary—such as redness or scalp sensitivity.

Complementary Treatments for Hair Loss

To enhance outcomes, exosome therapy may be combined with other hair restoration treatments, such as:

• Topical hair growth serums

• Oral supplements to support hair cycle balance

• Low-Level Laser Therapy (LLLT)

• Medical treatments

Our dermatologists will customise a holistic plan based on your needs and goals.

Frequently Asked Questions (FAQs)

Is the treatment painful?
A numbing cream is applied before the procedure, and most patients experience only mild discomfort.

How soon will I see results?
Results typically become visible after 8 to 12 weeks, with continued improvement over the following months.

Are exosomes better than PRP?
PRP is not an approved treatment for hair loss in Singapore.

Can I do this if I had a hair transplant?
Yes. Exosome therapy is often used to enhance the results of a hair transplant or maintain existing hair health.

Is this treatment approved in Singapore?
Exosome therapy is offered as a medical aesthetic treatment. We only use well-sourced, quality-controlled exosomes administered by qualified doctors in accordance with MOH guidelines and HSA requirements.

Start Your Hair Regrowth Journey Today

Read more about hair loss here. Link to hair loss page. If you’re seeking a non-surgical, regenerative solution to hair thinning or pattern baldness, exosome therapy may be right for you. Book a consultation at Shine Dermatology to explore your personalised treatment options with our experienced dermatologists.