Injectables - Polynucleotide Injections

What Are Polynucleotide Injections?

Polynucleotide injections are injectable treatments composed of purified DNA fragments, typically derived from salmon DNA. These DNA fragments activate natural cell repair processes and enhance skin resilience by improving hydration, elasticity, and tissue regeneration.

Unlike fillers that add volume or neuromodulators that reduce muscle activity, polynucleotides work by enhancing skin quality at a cellular level, making them ideal for thin, delicate, or inflamed skin.

How Do Polynucleotide Injections Work?

Polynucleotides act as biostimulators:

• They activate fibroblasts to increase collagen and elastin production

• Promote tissue repair and reduce oxidative stress

• Improve microcirculation and hydration levels

Once injected into the dermis, polynucleotides encourage regeneration of the extracellular matrix, leading to visibly smoother, stronger, and more radiant skin over time.

Benefits of Polynucleotide Injections

• Improves Skin Texture: Refines rough, uneven, or crepey skin

• Enhances Radiance: Boosts luminosity and clarity

• Restores Hydration: Ideal for dehydrated or compromised skin barriers

• Reduces Redness & Sensitivity: Supports skin recovery after inflammation or procedures

• Safe for Delicate Areas: Suitable for under-eye, neck, and perioral regions

• Minimal Downtime: Gentle formulation with low risk of bruising or swelling

When to Consider Polynucleotide Injections

Polynucleotide therapy is ideal for those experiencing:

• Dull, dehydrated, or fragile skin

• Post-acne sensitivity or redness

• Early fine lines or loss of elasticity

• Preparation or recovery from laser or microneedling treatments

• Prevention of aging in younger patients with stressed skin

Recommended Sessions & Recovery Timeline

Post-care Tips: Use a gentle cleanser, moisturiser, and broad-spectrum sunscreen. Avoid alcohol, heavy exercise, and actives like retinoids for 48 hours.

Safety & Side Effects

Polynucleotide injections are generally well tolerated, even in sensitive individuals. Side effects are mild and may include:

• Temporary redness or swelling at the injection site

• Mild tenderness for 1–2 days

• Rare small bruising (resolves in a few days)

At Shine Dermatology, treatments are performed using ultra-fine needles or cannulas under sterile conditions to minimise discomfort and risk.

Frequently Asked Questions (FAQ)

1. How are polynucleotide injections different from fillers or skinboosters?
   Polynucleotides do not add volume. They rejuvenate skin through cellular regeneration and hydration, not by filling or lifting.

2. Is the treatment safe for sensitive or eczema-prone skin?
   Yes. Polynucleotide injections are anti-inflammatory and help repair damaged skin barriers.

3. When will I see results?
   Improvements in texture and hydration are noticeable within 2–3 weeks; results continue to improve over months.

4. Can I combine this with other treatments?
   Absolutely. PN injections pair well with lasers, microneedling, and chemical peels to enhance overall outcomes.

5. Is there downtime?
   Minimal. You may have slight redness or bumps immediately post-treatment, which typically resolve within 24 hours.

6. Is the procedure painful?
   Discomfort is mild. A numbing cream is applied prior to treatment for comfort.

7. How long do results last?
   Maintenance is typically needed every 4–6 months after the initial protocol.

8. What are polynucleotides made from?
   They are derived from purified salmon DNA, known for their high biocompatibility and regenerative properties.

9. Can men benefit from PN treatments?
   Yes. Polynucleotide injections are excellent for post-shave irritation, environmental stress, or dullness in male skin.

10. Is this treatment suitable for all skin types?
    Yes. It is safe and effective for all skin types, including Asian and sensitive skin.

Book a Consultation Today

Rejuvenate your skin from within with polynucleotide injections at Shine Dermatology. Schedule a consultation with our medical team to create a customised skin revitalisation plan tailored to your needs.